The Tanglewood campus covers 526 acres in the scenic Berkshires of western Massachusetts. Located in the village of Lenox, it is close to the major cities of New England and New York, with many options for air travel. Driving time is 1 hour from Albany, NY, Hartford, CT, and Springfield, MA; 2 hours from Boston, MA; and 3 hours from New York, NY. Commercial bus service is available to Lenox from all of these cities.

The primary performance space for the TMC is Seiji Ozawa Hall, although TMC Fellows do also perform in the other spaces on the Tanglewood grounds, including the Tanglewood Theatre and the Koussevitsky Music Shed. In addition to the numerous rehearsal and practice spaces in use on campus, Tanglewood is also home to the Copland Library, which houses a substantial collection of books, chamber music and other scores, and recordings. Tanglewood also has two cafés and a gift shop.